反应详情

Dissolve (2-bromo-ethyl)-cyclohexane (10.0 g, 52.3 mmol) in 500 mL acetone, add sodium iodide (15.6 g, 104.6 mmol) and reflux over night. Filter the reaction mixture, add water to the filtrate and extract with hexane. Dry the organic phases over sodium sulfate, filter and concentrate to an oil. Further purify this material by distillation to afford the title compound (10.6 g). 1H-NMR (CDCl3) δ=0.83-1.00 (m, 2H), 1.07-1.48 (m, 4H), 1.61-1.80 (m, 7H), 3.16-3.27 (m, 2H).

1. temperaturereflux over night
2. filtrationFilter the reaction mixture
3. additionadd water to the filtrate
4. extractionextract with hexane
5. dry with materialDry the organic phases over sodium sulfate
6. filtrationfilter
7. concentrationconcentrate to an oil
8. customFurther purify this material
9. distillationby distillation