HCID 178452023, compound → HCID 178494068, compound

HRID 2103684Notes

Reaction equation

[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:36]=[CH:35][C:12]3[N:13]=[C:14]([C@@H:16]4[CH2:19][C@H:18]([N:20]5[CH2:27][C@@H:26]6[C@@H:22]([N:23](C(OC(C)(C)C)=O)[CH2:24][CH2:25]6)[CH2:21]5)[CH2:17]4)[S:15][C:11]=3[CH:10]=2)=[CH:5][N:4]=1.N1C=C(C2C=CC3N=C([C@@H]4C[C@H](N5C[C@@H]6[C@@H](N(C(OC(C)(C)C)=O)CC6)C5)C4)SC=3C=2)C=NC=1>>[NH:23]1[CH2:24][CH2:25][C@@H:26]2[CH2:27][N:20]([C@@H:18]3[CH2:19][C@H:16]([C:14]4[S:15][C:11]5[CH:10]=[C:9]([C:6]6[CH:5]=[N:4][C:3]([O:2][CH3:1])=[N:8][CH:7]=6)[CH:36]=[CH:35][C:12]=5[N:13]=4)[CH2:17]3)[CH2:21][C@H:22]12

Participants

Reactant 2

HCID 178452023HCID 178452023, compound

HCID 178494069HCID 178494069, compound

Product 1

HCID 178494068HCID 178494068, compound

Procedure

The title compound was prepared according to the procedure described in Example 38C, substituting the product of Example 39A for the product of Example 38B. 1H NMR (500 MHz, CDCl3) δ ppm 8.77 (s, 2H) 8.05 (d, J=8.54 Hz, 1H) 7.97 (s, 1H) 7.58 (dd, J=8.54, 1.83 Hz, 1H) 4.08 (s, 3H) 3.85-3.98 (m, 1H) 3.60-3.70 (m, 1H) 3.08-3.16 (m, 1H) 2.90-3.02 (m, 2H) 2.73-2.81 (m, 1H) 2.61-2.71 (m, 2H) 2.49-2.60 (m, 3H) 2.31-2.47 (m, 3H) 1.93-2.05 (m, 1H) 1.58-1.74 (m, 1H). MS: (M+H)+=408.

Sources & evidence

ORD record: ord-42566abd3244412eaea1d4651f823cb4
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576110B2

Reaction notes

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