3(2H)-Pyridazinone → HCID 178426920, compound

HRID 2103708Notes

Reaction equation

HRID 2103708 reaction equation
Br[C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([C@H:9]3[CH2:12][C@H:11]([N:13]4[CH2:17][CH2:16][CH2:15][C@H:14]4C)[CH2:10]3)[S:8][C:4]=2[CH:3]=1.[CH3:21][C:22]1[CH:23]=[CH:24][C:25](=[O:28])[NH:26][N:27]=1.N1NC(=O)C=CC=1>>[CH3:21][C:22]1[CH:23]=[CH:24][C:25](=[O:28])[N:26]([C:2]2[CH:20]=[CH:19][C:5]3[N:6]=[C:7]([C@H:9]4[CH2:10][C@H:11]([N:13]5[CH2:14][CH2:15][CH2:16][CH2:17]5)[CH2:12]4)[S:8][C:4]=3[CH:3]=2)[N:27]=1

Participants

4

Reactant 3

HCID 681533(2H)-PyridazinoneHCID 833466-methylpyridazin-3(2H)-oneHCID 178461421HCID 178461421, compound

Product 1

HCID 178426920HCID 178426920, compound

Procedure

The title compound was prepared according to the procedure described in Example 22, substituting the product of Example 62A for the product of Example 1E and substituting 6-methyl-3(2H)-pyridazinone for 3(2H)-pyridazinone. 1H NMR (300 MHz, CDCl3) δ ppm 8.12 (t, J=2.03 Hz, 1H) 8.03 (t, J=8.48 Hz, 1H) 7.66 (dd, J=8.48, 2.37 Hz, 1H) 7.17 (d, J=9.49, 1H) 7.00 (d, J=9.49 Hz, 1H) 3.56-3.72 (m, 1H) 3.07 (m, 1H) 2.48-2.78 (m, 6H) 2.41 (s, 3H) 1.87-1.96 (m, 2H) 1.77-1.87 (m, 2H) 1.49-1.73 (m, 2H). MS: (M+H)+=367.

Sources & evidence

ORD record
ord-80c2cf31607e4ffaa60119f433422d6b
Source dataset
uspto-grants-2009_08
Patent number
US07576110B2

Reaction notes

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