3(2H)-Pyridazinone → HCID 178426324, compound

HRID 2103710Notes

Reaction equation

HRID 2103710 reaction equation
Br[C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([C@H:9]3[CH2:12][C@H:11]([N:13]4[CH2:17][CH2:16][CH2:15][C@H:14]4C)[CH2:10]3)[S:8][C:4]=2[CH:3]=1.[CH3:21][C:22]1[C:23](=[O:28])[NH:24][CH:25]=[CH:26][CH:27]=1.N1NC(=O)C=CC=1>>[CH3:21][C:22]1[C:23](=[O:28])[N:24]([C:2]2[CH:20]=[CH:19][C:5]3[N:6]=[C:7]([C@H:9]4[CH2:12][C@H:11]([N:13]5[CH2:14][CH2:15][CH2:16][CH2:17]5)[CH2:10]4)[S:8][C:4]=3[CH:3]=2)[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 681533(2H)-PyridazinoneHCID 704812-Hydroxy-3-methylpyridineHCID 178461421HCID 178461421, compound

Product 1

HCID 178426324HCID 178426324, compound

Procedure

The title compound was prepared according to the procedure described in Example 22, substituting the product of Example 62A for the product of Example 1E and substituting 3-methyl-2-pyridone for 3(2H)-pyridazinone. 1H NMR (300 MHz, CDCl3) δ ppm 8.03 (t, J=8.31 Hz, 1H) 7.89 (d, J=2.03 Hz, 1H) 7.44 (t, 1H) 7.27-7.33 (m, 1H) 6.18 (q, 2H) 3.55-3.75 (m, 1H) 3.03-3.15 (m, 1H) 2.39-2.76 (m, 6H) 2.21 (s, 3H) 1.79-1.99 (m, 4H) 1.50-1.70 (m, 2H). MS: (M+H)+=366.

Sources & evidence

ORD record
ord-ab018def978a4040ace8d48d34bd636f
Source dataset
uspto-grants-2009_08
Patent number
US07576110B2

Reaction notes

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