反应详情

温度

70 °C

4-Trifluoromethylacetophenone (11.14 mmol, 2.096 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After 9.5 hours of stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water and stirred for about 16 hours. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (1.3116 g, yield 59%).

1. temperaturethe reactor was cooled to room temperature
2. stirringstirred for about 16 hours
3. filtrationThe precipitated solid was recovered by filtration
4. washwashed with water
5. customdried by means of a vacuum pump