Hydrogen Bromide → HCID 12438220, compound

HRID 2103795Notes

Reaction equation

HRID 2103795 reaction equation
[CH3:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:11])=[O:10])=[CH:5][CH:4]=1.Br.[OH2:13]>CS(C)=O>[CH2:2]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:10])[CH:11]=[O:13])=[CH:5][CH:4]=1)[CH3:1]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 136424'-Ethylacetophenone

Product 1

HCID 12438220HCID 12438220, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
70 °C

Procedure

4-Ethylacetophenone (26.72 mmol, 4 mL) was dissolved in dimethyl sulfoxide (27 mL), and 48% hydrobromic acid (11 mL) was gradually added at room temperature. After overnight stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water (50 mL) and stirred for about 1 hour. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a white solid (2.44 g, yield 56%).

Workup

  1. temperaturethe reactor was cooled to room temperature
  2. stirringstirred for about 1 hour
  3. filtrationThe precipitated solid was recovered by filtration
  4. washwashed with water
  5. customdried by means of a vacuum pump

Sources & evidence

ORD record
ord-14a9347ccb8b4aab8f011a6a1864f260
Source dataset
uspto-grants-2009_08
Patent number
US07576115B2

Reaction notes

Loading…