Hydrochloric Acid → HCID 72360091, compound

HRID 2103920Notes

Reaction equation

HRID 2103920 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:17][C:18]([NH:20][N:21]=[C:22]([C:24]2[C:28]([OH:29])=[C:27]([C:30]3[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=3)[N:26]([CH3:40])[N:25]=2)[CH3:23])=[S:19])=[C:6]([CH:16]=1)[O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12].[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:17][C:18]([NH:20][N:21]=[C:22]([C:24]2[C:28]([OH:29])=[C:27]([C:30]3[CH:31]=[CH:32][C:33]([C:36]([F:38])([F:37])[F:39])=[CH:34][CH:35]=3)[N:26]([CH3:40])[N:25]=2)[CH3:23])=[S:19])=[C:6]([CH:16]=1)[O:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 72360020HCID 72360020, compound

Product 1

HCID 72360091HCID 72360091, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of ethyl 4-(5-chloro-2-{[(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-phenoxy)butyrate (74 mg, 0.12 mmol) in ethanol (3.0 mL) was added 1 M aqueous sodium hydroxide (370 μL, 0.37 mmol). After the reaction mixture was stirred at room temperature for 19 hours, 1 M hydrochloric acid (370 μL, 0.37 mmol) was added then the precipitated solid was collected by filtration, washed with chloroform and dried by means of a vacuum pump to give the desired product as a yellow solid (yield 59%).

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with chloroform
  3. customdried by means of a vacuum pump

Sources & evidence

ORD record
ord-43ebf987c6d54ea8b4dcf1aa3f1b8a3b
Source dataset
uspto-grants-2009_08
Patent number
US07576115B2

Reaction notes

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