1,4-Diiodobutane → HCID 178420929, compound

HRID 2103941Notes

Reaction equation

HRID 2103941 reaction equation
[SH:1][C:2]1[NH:6][N:5]=[N:4][CH:3]=1.I[CH2:8][CH2:9][CH2:10][CH2:11]I>C(O)C>[N:4]1[CH:3]=[C:2]([S:1][CH2:8][CH2:9][CH2:10][CH2:11][S:1][C:2]2[NH:6][N:5]=[N:4][CH:3]=2)[NH:6][N:5]=1

Participants

4

Reactant 2

HCID 123371,4-DiiodobutaneHCID 178527741HCID 178527741, compound2×

Product 1

HCID 178420929HCID 178420929, compoundYield 70.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

20 mmole of 5-mercapto-1H-1,2,3-triazole (sodium salt) was dissolved in 20 ml of ethanol in stirring. 10 mmole of 1,4-diiodobutane was added dropwise to the solution of 5-mercapto-1H-1,2,3-triazole (sodium salt), and stirred overnight. After the solvent was evaporated in vacuum, the residual was washed with 50 ml pure H2O for three times, and then with 50 ml hexane for 3 times. At last, the residual was dried in oven at 60° C. for 24 hours. 1.8 g product was obtained as white solid. Yield: 70%. 1H NMR (DMSO): δ (ppm) 7.86 (2H, s), 2.85 (4H, m), and 1.66 (4H, m).

Workup

  1. stirringstirred overnight
  2. customAfter the solvent was evaporated in vacuum
  3. washthe residual was washed with 50 ml pure H2O for three times
  4. customAt last, the residual was dried in oven at 60° C. for 24 hours

Sources & evidence

ORD record
ord-fb9bd4c7727a42fd93ef439a0084a35b
Source dataset
uspto-grants-2009_08
Patent number
US07576165B2

Reaction notes

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