反应详情

4-chloro-4'-ethane sulfonylmethylbenzhydrol (6.0 g), thionyl chloride (5.4 g), toluene (200 ml) and a catalytic amount of N,N-dimethylformamide were mixed and gradually heated with stirring to a refluxing temperature. The mixture was stirred for 4 hours under reflux and then left to cool. Then, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1) to obtain the desired product as a slight yellow viscous substance (4.6 g, nD20 : 1.6044, yield: 75%).

1. temperaturegradually heated
2. stirringThe mixture was stirred for 4 hours
3. temperatureunder reflux
4. waitleft
5. temperatureto cool
6. distillationThen, the solvent was distilled off under reduced pressure
7. customThe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1)