Isopropanol → HCID 11611790, compound

HRID 2104151Notes

Reaction equation

HRID 2104151 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=1)=O.[F:22][C:23]([F:31])([F:30])[C:24](=[O:29])[CH2:25][C:26](=O)[CH3:27].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[Cl:21][C:17]1[CH:16]=[C:15]([C:13]2[C:3]3[C:2](=[CH:7][CH:6]=[C:5]([O:8][C:9]([F:12])([F:11])[F:10])[CH:4]=3)[N:1]=[C:26]([CH3:27])[C:25]=2[C:24](=[O:29])[C:23]([F:31])([F:30])[F:22])[CH:20]=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 67549809HCID 67549809, compound

Product 1

HCID 11611790HCID 11611790, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-trifluoromethoxy-phenyl)-(3-chloro-phenyl)-methanone [example A7] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 60 h and heptane/ethyl acetate (1:2) was used. Yield: 58%; MS: m/z=433 (M).

Sources & evidence

ORD record
ord-1dd39c62d68a442db6048829085dbc84
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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