Isopropanol → HCID 11510326, compound

HRID 2104153Notes

Reaction equation

HRID 2104153 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[C:13]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)=O.[F:22][C:23]([F:31])([F:30])[C:24](=[O:29])[CH2:25][C:26](=O)[CH3:27].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:13]2[C:3]3[C:2](=[CH:7][CH:6]=[C:5]([O:8][C:9]([F:12])([F:11])[F:10])[CH:4]=3)[N:1]=[C:26]([CH3:27])[C:25]=2[C:24](=[O:29])[C:23]([F:31])([F:30])[F:22])=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 68405958HCID 68405958, compound

Product 1

HCID 11510326HCID 11510326, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-trifluoromethoxy-phenyl)-(4-chloro-phenyl)-methanone [example A3] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 34%; MS: m/z=433 (M).

Sources & evidence

ORD record
ord-95e091e700d74ee3a14677389ee899fb
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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