Isopropanol → HCID 11531786, compound

HRID 2104156Notes

Reaction equation

HRID 2104156 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[C:13]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)=O.[F:22][C:23]([F:31])([F:30])[C:24](=[O:29])[CH2:25][C:26](=O)[CH3:27].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[F:22][C:23]([F:31])([F:30])[C:24]([C:25]1[C:26]([CH3:27])=[N:1][C:2]2[C:3]([C:13]=1[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)=[CH:4][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:7]=2)=[O:29]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 68413052HCID 68413052, compound

Product 1

HCID 11531786HCID 11531786, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-trifluoromethoxy-phenyl)-(4-fluoro-phenyl)-methanone [example A9] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 96%; MS: m/z=417 (M).

Sources & evidence

ORD record
ord-da2321a0876544998ff81bb089c45461
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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