Isopropanol → HCID 11552460, compound

HRID 2104157Notes

Reaction equation

HRID 2104157 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O.[F:20][C:21]([F:29])([F:28])[C:22](=[O:27])[CH2:23][C:24](=O)[CH3:25].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[C:8]([C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:24]([CH3:25])[C:23]([C:22](=[O:27])[C:21]([F:29])([F:28])[F:20])=[C:12]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([CH3:11])([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 67548637HCID 67548637, compound

Product 1

HCID 11552460HCID 11552460, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-tert-butyl-phenyl)-phenyl-methanone [example A1] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 37%; MS: m/z=372 (M+H).

Sources & evidence

ORD record
ord-66648dc635784777aec9633cb131fc48
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

Loading…