Isopropanol → HCID 11603598, compound

HRID 2104158Notes

Reaction equation

HRID 2104158 reaction equation
[NH2:1][C:2]1[C:3]([C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=O)=[CH:4][C:5]2[O:9][C:8]([F:11])([F:10])[O:7][C:6]=2[CH:12]=1.[F:21][C:22]([F:30])([F:29])[C:23](=[O:28])[CH2:24][C:25](=O)[CH3:26].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[F:10][C:8]1([F:11])[O:9][C:5]2=[CH:4][C:3]3[C:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)=[C:24]([C:23](=[O:28])[C:22]([F:30])([F:29])[F:21])[C:25]([CH3:26])=[N:1][C:2]=3[CH:12]=[C:6]2[O:7]1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 67549426HCID 67549426, compound

Product 1

HCID 11603598HCID 11603598, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (6-Amino-2,2-difluoro-benzo[1,3]dioxol-5-yl)-phenyl-methanone [example A10] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 30%; MS: m/z=396 (M+H).

Sources & evidence

ORD record
ord-7ac350692ddd4d86b360e9e8a57d8c65
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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