Isopropanol → HCID 11546573, compound

HRID 2104159Notes

Reaction equation

HRID 2104159 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[C:13]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([F:22])[CH:16]=1)=O.[F:23][C:24]([F:32])([F:31])[C:25](=[O:30])[CH2:26][C:27](=O)[CH3:28].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[F:22][C:17]1[CH:16]=[C:15]([C:13]2[C:3]3[C:2](=[CH:7][CH:6]=[C:5]([O:8][C:9]([F:12])([F:11])[F:10])[CH:4]=3)[N:1]=[C:27]([CH3:28])[C:26]=2[C:25](=[O:30])[C:24]([F:32])([F:31])[F:23])[CH:20]=[CH:19][C:18]=1[F:21]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 68406979HCID 68406979, compound

Product 1

HCID 11546573HCID 11546573, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-trifluoromethoxy-phenyl)-(3,4-difluoro-phenyl)-methanone [example A12] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 36%; MS: m/z=435 (M).

Sources & evidence

ORD record
ord-d68c9895024847eab61951bf95d41427
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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