Isopropanol → HCID 11698609, compound

HRID 2104160Notes

Reaction equation

HRID 2104160 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[C:13]([C:15]1[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=1)=O.[F:25][C:26]([F:34])([F:33])[C:27](=[O:32])[CH2:28][C:29](=O)[CH3:30].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[F:25][C:26]([F:34])([F:33])[C:27]([C:28]1[C:29]([CH3:30])=[N:1][C:2]2[C:3]([C:13]=1[C:15]1[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=1)=[CH:4][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:7]=2)=[O:32]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 67549333HCID 67549333, compound

Product 1

HCID 11698609HCID 11698609, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-trifluoromethoxy-phenyl)-(4-methanesulfonyl-phenyl)-methanone [example A 13] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 45%; MS: m/z=477 (M).

Sources & evidence

ORD record
ord-74037e6a87324dc0a297f7004b41c598
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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