Azepane → HCID 11697257, compound

HRID 2104181Notes

Reaction equation

HRID 2104181 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]2[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[NH:25]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[N:25]1([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]=[C:7]([CH3:12])[C:6]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]3[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 8119AzepaneHCID 11710932HCID 11710932, compound

Product 1

HCID 11697257HCID 11697257, compoundYield 14%

Procedure

The title compound was prepared from 1-(6-Bromo-2-methyl-4-phenyl-quinolin-3-yl)-2,2,2-trifluoro-ethanone [example 3] and azepane according to the procedure of example 25, except that the reaction time was of 16 h. Yield: 14%; MS: m/z=413 (M+H).

Sources & evidence

ORD record
ord-23ecf3068e5b46ac93938cd39a38f914
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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