3,3-Difluoropiperidine hydrochloride → HCID 11504451, compound

HRID 2104190Notes

Reaction equation

HRID 2104190 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]2[C:19]1[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=1.Cl.[F:30][C:31]1([F:37])[CH2:36][CH2:35][CH2:34][NH:33][CH2:32]1>>[F:30][C:31]1([F:37])[CH2:36][CH2:35][CH2:34][N:33]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]=[C:7]([CH3:12])[C:6]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]3[C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)[CH2:32]1

Participants

3

Reactant 2

HCID 27583493,3-Difluoropiperidine hydrochlorideHCID 115400851-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone

Product 1

HCID 11504451HCID 11504451, compoundYield 50%

Procedure

The title compound was prepared from 1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 23] and 3,3-difluoropiperidine hydrochloride according to the procedure of example 51. Yield: 50%; MS: m/z=. 513 (M+H).

Sources & evidence

ORD record
ord-a1823cce808c46d2b7f30b2f4f1b9d1c
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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