HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Difluoropiperidine hydrochloride → 1-[6-(3,3-Difluoro-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Difluoropiperidine hydrochloride | HCID 2758349 | — |
| Reactant | 1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone | HCID 11540085 | — |
| Product | 1-[6-(3,3-Difluoro-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone | HCID 11504451 | 50% |
Reaction Steps
The title compound was prepared from 1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 23] and 3,3-difluoropiperidine hydrochloride according to the procedure of example 51. Yield: 50%; MS: m/z=. 513 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576217B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-a1823cce808c46d2b7f30b2f4f1b9d1c |
| Source note | uspto-grants-2009_08 |