Piperidine → HCID 11604796, compound

HRID 2104192Notes

Reaction equation

HRID 2104192 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]([C:13]([CH:15]1[CH2:17][CH2:16]1)=[O:14])=[C:5]2[C:18]1[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=1.[NH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH:15]1([C:13]([C:6]2[C:7]([CH3:12])=[N:8][C:9]3[C:4]([C:5]=2[C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=2)=[CH:3][C:2]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:11][CH:10]=3)=[O:14])[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 11704924HCID 11704924, compound

Product 1

HCID 11604796HCID 11604796, compoundYield 39%

Procedure

The title compound was prepared from [6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-cyclopropyl-methanone [example 50] and piperidine according to the procedure of example 51. Yield: 39%; MS: m/z=449 (M+H).

Sources & evidence

ORD record
ord-cb70a814eb0645669b7174ddd27558bd
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

Loading…