Isopropanol → HCID 11632004, compound

HRID 2104193Notes

Reaction equation

HRID 2104193 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O.[CH:17]1([C:20](=[O:25])[CH2:21][C:22](=O)[CH3:23])[CH2:19][CH2:18]1.C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[Br:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:22]([CH3:23])[C:21]([C:20]([CH:17]1[CH2:19][CH2:18]1)=[O:25])=[C:9]2[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 996772-Amino-5-bromobenzophenoneHCID 110188691-Cyclopropyl-butane-1,3-dione

Product 1

HCID 11632004HCID 11632004, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-amino-5-bromo-phenyl)-phenyl-methanone [example A16] and 1-cyclopropyl-1,3-butanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 75%; MS: m/z=366 (M).

Sources & evidence

ORD record
ord-dc7b5879c3bb4e8290c3277de44249a3
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

Loading…