Hydroxyamine hydrochloride → HCID 178427939, compound

Participants

Reaction Steps

In a 4 mL vial was added 50 mg of 1-[2-(4-chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-4-(4-chloro-phenyl)-piperidine-4-carbonitrile (0.1 mmol, 1.00 eq), 24 mg hydroxylamine hydrochloride (0.33 mmol, 3.00 eq), 94uL TEA (0.66 mmol, 6.00 eq), and 500uL ethanol. The mixture was heated to 55C overnight and the solvent removed in vacuo. The crude material was used “as is” in the following step:

Provenance & Evidence