Hydroxyamine hydrochloride → HCID 178427939, compound

HRID 2104242Notes

Reaction equation

HRID 2104242 reaction equation
[Cl:1][C:2]1[C:3]([C:26]([F:29])([F:28])[F:27])=[N:4][N:5]([CH2:8][C:9]([N:11]2[CH2:16][CH2:15][C:14]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)([C:17]#[N:18])[CH2:13][CH2:12]2)=[O:10])[C:6]=1[CH3:7].Cl.[NH2:31][OH:32]>C(O)C>[Cl:1][C:2]1[C:3]([C:26]([F:29])([F:28])[F:27])=[N:4][N:5]([CH2:8][C:9]([N:11]2[CH2:16][CH2:15][C:14]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)([C:17]([NH:31][OH:32])=[NH:18])[CH2:13][CH2:12]2)=[O:10])[C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 16048547HCID 16048547, compound

Product 1

HCID 178427939HCID 178427939, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a 4 mL vial was added 50 mg of 1-[2-(4-chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-4-(4-chloro-phenyl)-piperidine-4-carbonitrile (0.1 mmol, 1.00 eq), 24 mg hydroxylamine hydrochloride (0.33 mmol, 3.00 eq), 94uL TEA (0.66 mmol, 6.00 eq), and 500uL ethanol. The mixture was heated to 55C overnight and the solvent removed in vacuo. The crude material was used “as is” in the following step:

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-420e28b2eb2844fa845d60da62af35f7
Source dataset
uspto-grants-2009_08
Patent number
US07576218B2

Reaction notes

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