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HRID2104252

反应详情

EQUATION

反应方程式

HRID 2104252 的结构方程式

REACTANTS

反应物

2
结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：COc1cc(CO)ccc1Cl
HCID10910038

(4-chloro-3-methoxyphenyl)methanol

C8H9ClO2

PRODUCTS

生成物

1
结构：COc1cc(CCl)ccc1Cl
HCID57609443

1-Chloro-4-(chloromethyl)-2-methoxybenzene

C8H8Cl2O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

4-chloro-3-methoxybenzyl alcohol (5 g, 1 equiv) in 15 mL of DCM was treated with thionyl chloride (5 mL, 3 equiv) at reflux for 2 hours. Evaporation of volatiles gave 4-chloro-3-methoxybenzyl chloride.

WORKUP

后处理

  1. temperatureat reflux for 2 hours
  2. customEvaporation of volatiles