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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104252Generated: October 30, 2026

Thionyl Chloride → 1-Chloro-4-(chloromethyl)-2-methoxybenzene

https://huagongshe.com/reaction/2104252

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant(4-Chloro-3-methoxyphenyl)methanolHCID 10910038—
SolventDichloromethaneHCID 6344—
Product1-Chloro-4-(chloromethyl)-2-methoxybenzeneHCID 57609443—

Reaction Steps

4-chloro-3-methoxybenzyl alcohol (5 g, 1 equiv) in 15 mL of DCM was treated with thionyl chloride (5 mL, 3 equiv) at reflux for 2 hours. Evaporation of volatiles gave 4-chloro-3-methoxybenzyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576218B2
Source datasetuspto-grants-2009_08
ORD IDord-52eddf484771457cb05304c56c958fe5
Source noteuspto-grants-2009_08