5-Methoxyindole → 5-Methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole

HRID 2104304Notes

Reaction equation

HRID 2104304 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2.[NH:12]1[CH2:17][CH2:16][C:15](O)(O)[CH2:14][CH2:13]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[C:15]1[CH2:16][CH2:17][NH:12][CH2:13][CH:14]=1

Participants

3

Reactant 2

HCID 138725-MethoxyindoleHCID 3853601Piperidine-4,4-diol

Product 1

HCID 1080295-Methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole

Procedure

The experimental protocol used is described in the literature (Eur. J. Med. Chem. (1987) 22, 33-43), starting from 5-methoxy-1H-indole and 4,4-piperidinediol.

Sources & evidence

ORD record
ord-addf11ad33bb4fdb9b18ec2f241f4d05
Source dataset
uspto-grants-2009_08
Patent number
US07576241B2

Reaction notes

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