HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → (2E)-5-Amino-3,5-dimethylhex-2-enoic acid N-((1R)-2-(biphenyl-4-yl)-1-{N-[(1R)-2-(4-hydroxypiperidin-1-yl)-2-oxo-1-((2-thienyl)methyl)ethyl]-N-methylcarbamoyl}ethyl)-N-methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | (2E)-5-tert-Butoxycarbonylamino-3,5-dimethylhex-2-enoic acid | HCID 10753633 | — |
| Reactant | N-Boc-N-methyl-3-(biphenyl-4-yl)-D-alanine | HCID 20694694 | — |
| Reactant | (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(2-thienyl)propionic acid | HCID 54365014 | — |
| Product | (2E)-5-Amino-3,5-dimethylhex-2-enoic acid N-((1R)-2-(biphenyl-4-yl)-1-{N-[(1R)-2-(4-hydroxypiperidin-1-yl)-2-oxo-1-((2-thienyl)methyl)ethyl]-N-methylcarbamoyl}ethyl)-N-methylamide | HCID 10952382 | — |
Reaction Steps
This compound was prepared as in example 1 but using 4-hydroxypiperidine, (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(2-thienyl)propionic acid and (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(biphenyl-4-yl)propionic acid and (2E)-5-tert-butoxycarbonylamino-3,5-dimethylhex-2-enoic acid as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576062B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-95389608975b423db43fac8ffd0ef7b7 |
| Source note | uspto-grants-2009_08 |