反应详情

A mixture of 3-chloro-4-fluoro-α-azidocinnamic acid methyl ester (Japanese Patent Application Laid-Open (kokai). No. 7-149723) (1.85 g) and xylene (140 mL) was heated under reflux for 1 hour, and the solvent was distilled away. The residue was purified by silica gel column chromatography (methylene chloride), to thereby give the title compound (491 mg).

1. temperatureunder reflux for 1 hour
2. distillationthe solvent was distilled away
3. customThe residue was purified by silica gel column chromatography (methylene chloride)