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HRID2104372

反应详情

EQUATION

反应方程式

HRID 2104372 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1
HCID70670

Acetic acid, (triphenylphosphoranylidene)-, ethyl ester

C22H21O2P

结构：CC(C)(C)OC(=O)N1[C@@H](C=O)COC1(C)C
HCID178792

tert-Butyl 4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

C11H19NO4

PRODUCTS

生成物

1
结构：CCOC(=O)/C=C/[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C
HCID10732902

未命名化合物

收率 111.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A mixture comprising (4R)-4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylic acid tert-butyl ester (11.7 g), (carbethoxymethylene)triphenylphosphorane (20.7 g), and toluene (100 mL) was stirred at 100° C. for 18 hours. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1), to thereby give the title compound (17 g).

WORKUP

后处理

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1)