Water → HCID 57432610, compound

HRID 2104388Notes

Reaction equation

HRID 2104388 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.C(N(CC)CC)C.Cl[C:17](=[O:22])[C:18]([O:20][CH3:21])=[O:19].O>N1C=CC=CC=1>[CH3:21][O:20][C:18](=[O:19])[C:17]([NH:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1)=[O:22]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 216436-Amino-3-chloropyridazineHCID 79846Methyl chloroglyoxylate

Product 1

HCID 57432610HCID 57432610, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Amino-6-chloropyridazine (516 mg) was dissolved in pyridine (26 mL), and to the solution were sequentially added triethylamine (665 mL) and methyl chlorooxoacetate (441 μL) under ice cooling, followed by stirring at room temperature for 14 hours. Water was added to the reaction mixture to partition the mixture, and the organic layer was dried over sodium sulfate anhydrate. The solvent was distilled away under reduced pressure, to thereby give the title compound (748 mg).

Workup

  1. customto partition the mixture
  2. dry with materialthe organic layer was dried over sodium sulfate anhydrate
  3. distillationThe solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-3d0921421f694260a139689d9935fd23
Source dataset
uspto-grants-2009_08
Patent number
US07576135B2

Reaction notes

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