Chloroacetyl chloride → HCID 13143819, compound

HRID 2104423Notes

Reaction equation

HRID 2104423 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>CN(C)C=O>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1)=[O:12]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 216436-Amino-3-chloropyridazine

Product 1

HCID 13143819HCID 13143819, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Amino-6-chloropyridazine (10.4 g) was dissolved in N,N-dimethylformamide (200 mL). Chloroacetyl chloride (7.48 mL) was added thereto, and the resultant mixture was stirred at room temperature for 1 hour. The solvent was distilled away under reduced pressure, and ethyl acetate and saturated aqueous sodium hydrogencarbonate were added to the residue. The precipitated solid was recoverd by filtration, followed by washing with ethyl acetate and water, to thereby give the title compound (9.39 g).

Workup

  1. distillationThe solvent was distilled away under reduced pressure, and ethyl acetate and saturated aqueous sodium hydrogencarbonate
  2. additionwere added to the residue
  3. filtrationThe precipitated solid was recoverd by filtration
  4. washby washing with ethyl acetate and water

Sources & evidence

ORD record
ord-3b408c4f833248fea28160d2000118b5
Source dataset
uspto-grants-2009_08
Patent number
US07576135B2

Reaction notes

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