Trifluoroacetic acid → HCID 67056716, compound

HRID 2104458Notes

Reaction equation

HRID 2104458 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:16][C@H:15]1[NH:25][C:26]([C:28]1[N:29]=[CH:30][C:31]3[CH2:36][N:35]([C:37](OC(C)(C)C)=O)[CH2:34][C:32]=3[N:33]=1)=[O:27])=[O:12])=[CH:5]2.FC(F)(F)C(O)=O>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:16][C@H:15]1[NH:25][C:26]([C:28]1[N:29]=[CH:30][C:31]3[CH2:36][N:35]([CH3:37])[CH2:34][C:32]=3[N:33]=1)=[O:27])=[O:12])=[CH:5]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59677040HCID 59677040, compound

Product 1

HCID 67056716HCID 67056716, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (367 mg) obtained in Example 237 was dissolved in methylene chloride (10 mL), and trifluoroacetic acid (10 mL) was added, followed by stirring at room temperature for 2 hours. The reaction mixture was dried to solid under reduced pressure. The title compound was obtained from the thus-obtained crude product and formalin in a similar manner to the process described in Example 18.

Workup

  1. customThe reaction mixture was dried to solid under reduced pressure

Sources & evidence

ORD record
ord-dad35a009ab34b08924361b605a22ae3
Source dataset
uspto-grants-2009_08
Patent number
US07576135B2

Reaction notes

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