3-Aminopyridine → HCID 19937864, compound

HRID 2104459Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.Cl[C:9](=[O:14])[C:10]([O:12][CH3:13])=[O:11]>>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:9](=[O:14])[C:10]([O:12][CH3:13])=[O:11])[CH:3]=1

Participants

Reactant 2

HCID 100093-Aminopyridine

HCID 79846Methyl chloroglyoxylate

Product 1

HCID 19937864HCID 19937864, compound

Procedure

In a manner similar to that described in Referential Example 242, 3-aminopyridine was condensed with methyl 2-chloro-2-oxoacetate to form methyl 2-[(pyridin-3-yl)amino]-2-oxoacetate. In a manner similar to that described in Example 271, the title compound was obtained from the thus-condensed ester product and the compound obtained in Referential Example 310.

Sources & evidence

ORD record: ord-6fcd23a0a8c94a6d805343c38e01b180
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576135B2

Reaction notes

Loading…