Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone → 4-(4-Tert-butylphenyl)-3-(pyridin-2-ylmethyl)-8-(trifluoromethyl)quinoline

HRID 2104491Notes

Reaction equation

HRID 2104491 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[C:15](=[C:16]([C:21]([F:24])([F:23])[F:22])[CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][C:12]=2[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C1(C(C2C=NC3C(C=2C2C=CC=CC=2)=CC=CC=3C(F)(F)F)=O)C=CC=CC=1>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:20]3[C:15](=[C:16]([C:21]([F:22])([F:24])[F:23])[CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][C:12]=2[CH2:25][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 11360909Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanoneHCID 11453296[4-(4-Tert-Butylphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

Product 1

HCID 669132054-(4-Tert-butylphenyl)-3-(pyridin-2-ylmethyl)-8-(trifluoromethyl)quinoline

Procedure

This compound was prepared using the procedure of Example 31 substituting [4-(4-tert-butylphenyl)-8-(trifluoromethyl)quinolin-3-yl](pyridin-2-yl)methanone. of Example 18 for 2 phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone. MS (ESI) m/z 421 ([M+H]+); Anal. Calcd for C26H23F3N2: C, 74.27; H, 5.51; N, 6.66. Found: C, 73.94; H, 5.30; N, 6.53.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-88908204b773428e889de766e8a77d4b
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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