Phenyl isocyanate → HCID 66914232, compound

HRID 2104521Notes

Reaction equation

HRID 2104521 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([C:16]=2[C:17]2[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=2)=[CH:14][CH:13]=[CH:12][C:11]=3[C:24]([F:27])([F:26])[F:25])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:28]1([N:34]=[C:35]=[O:36])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(N(CC)CC)C>[C:28]1([NH:34][C:35]([NH:23][C:19]2[CH:20]=[CH:21][CH:22]=[C:17]([C:16]3[C:15]4[C:10](=[C:11]([C:24]([F:27])([F:25])[F:26])[CH:12]=[CH:13][CH:14]=4)[N:9]=[CH:8][C:7]=3[C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:18]=2)=[O:36])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 66913717{3-[3-Phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine

Product 1

HCID 66914232HCID 66914232, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared from {3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine and phenyl isocyanate in substantially the same manner as described in Example 61 with one change: no triethylamine was used; off-white solid: mp 202-205° C.; MS (ES) m/z 481.8.

Sources & evidence

ORD record
ord-d2dde9dd47c7432bbc3e8b40198e211b
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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