Chlorophenyl isocyanate → HCID 66914194, compound

HRID 2104522Notes

Reaction equation

HRID 2104522 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([C:16]=2[C:17]2[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=2)=[CH:14][CH:13]=[CH:12][C:11]=3[C:24]([F:27])([F:26])[F:25])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[N:35]=[C:36]=[O:37]>C(N(CC)CC)C>[Cl:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[NH:35][C:36]([NH:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:16]2[C:15]3[C:10](=[C:11]([C:24]([F:27])([F:25])[F:26])[CH:12]=[CH:13][CH:14]=3)[N:9]=[CH:8][C:7]=2[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:18]=1)=[O:37]

Participants

4

Reactant 2

HCID 76833Chlorophenyl isocyanateHCID 66913717{3-[3-Phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine

Product 1

HCID 66914194HCID 66914194, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared from {3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine and 2-chlorophenyl isocyanate in substantially the same manner as described in Example 61 with one change: no triethylamine was used; off-white solid: mp 192-195° C.; MS (ES) m/z 515.8.

Sources & evidence

ORD record
ord-5c14553af95c4597809ede0dd68ea852
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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