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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104580Generated: October 29, 2026

Lithium Hydroxide → 4-{[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Carbonyl]Amino}Benzoic Acid

https://huagongshe.com/reaction/2104580

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
ReactantEthyl 4-{[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Carbonyl]Amino}BenzoateHCID 66914066—
Product4-{[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Carbonyl]Amino}Benzoic AcidHCID 66914344—

Reaction Steps

The title compound was prepared from ethyl 4-{[({3-[3-benzoyl-8-(trifluoromethyl) quinolin-4-yl]phenyl}amino)carbonyl]amino}benzoate by hydrolysis with LiOH. HRMS: calcd for C31H20F3N3O4, 555.1406; found (ESI, [M+H]+), 556.1495.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576215B2
Source datasetuspto-grants-2009_08
ORD IDord-192dbbafbacc47889082ce8322bbbdc4
Source noteuspto-grants-2009_08