Lithium Hydroxide → 4-{[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Carbonyl]Amino}Benzoic Acid

HRID 2104580Notes

Reaction equation

HRID 2104580 reaction equation
[C:1]([C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[C:19]1[CH:20]=[C:21]([NH:25][C:26]([NH:28][C:29]3[CH:39]=[CH:38][C:32]([C:33]([O:35]CC)=[O:34])=[CH:31][CH:30]=3)=[O:27])[CH:22]=[CH:23][CH:24]=1)=[CH:16][CH:15]=[CH:14][C:13]=2[C:40]([F:43])([F:42])[F:41])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li+].[OH-]>>[C:1]([C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[C:19]1[CH:20]=[C:21]([NH:25][C:26]([NH:28][C:29]3[CH:30]=[CH:31][C:32]([C:33]([OH:35])=[O:34])=[CH:38][CH:39]=3)=[O:27])[CH:22]=[CH:23][CH:24]=1)=[CH:16][CH:15]=[CH:14][C:13]=2[C:40]([F:43])([F:41])[F:42])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 66914066Ethyl 4-{[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Carbonyl]Amino}Benzoate

Product 1

HCID 669143444-{[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Carbonyl]Amino}Benzoic Acid

Procedure

The title compound was prepared from ethyl 4-{[({3-[3-benzoyl-8-(trifluoromethyl) quinolin-4-yl]phenyl}amino)carbonyl]amino}benzoate by hydrolysis with LiOH. HRMS: calcd for C31H20F3N3O4, 555.1406; found (ESI, [M+H]+), 556.1495.

Sources & evidence

ORD record
ord-192dbbafbacc47889082ce8322bbbdc4
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

Loading…