4-(3-Allyl-4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-benzaldehyde → 3-Allyl-5-{4-[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Methyl]Benzylidene}-2-THIOXO-1,3-Thiazolidin-4-One

HRID 2104585Notes

Reaction equation

HRID 2104585 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[N:11]=[CH:10][C:9]=2[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:23])[CH:5]=[CH:6][CH:7]=1.[CH2:30]([N:33]1[C:37](=[O:38])[C:36](=[CH:39][C:40]2[CH:47]=[CH:46][C:43]([CH:44]=O)=[CH:42][CH:41]=2)[S:35][C:34]1=[S:48])[CH:31]=[CH2:32]>>[CH2:30]([N:33]1[C:37](=[O:38])[C:36](=[CH:39][C:40]2[CH:41]=[CH:42][C:43]([CH2:44][NH:1][C:2]3[CH:7]=[CH:6][CH:5]=[C:4]([C:8]4[C:17]5[C:12](=[C:13]([C:18]([F:21])([F:19])[F:20])[CH:14]=[CH:15][CH:16]=5)[N:11]=[CH:10][C:9]=4[C:22](=[O:23])[C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:3]=3)=[CH:46][CH:47]=2)[S:35][C:34]1=[S:48])[CH:31]=[CH2:32]

Participants

3

Reactant 2

HCID 3493504-(3-Allyl-4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-benzaldehydeHCID 11326798[4-(3-Aminophenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)Methanone

Product 1

HCID 728276833-Allyl-5-{4-[({3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Methyl]Benzylidene}-2-THIOXO-1,3-Thiazolidin-4-One

Procedure

The title compound was prepared from [4-(3-amino-phenyl)-8-trifluoromethyl-quinolin-3-yl]-phenyl-methanone and 4-(3-allyl-4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-benzaldehyde according to the procedure of Example 66. MS (ES) m/z 663.8.

Sources & evidence

ORD record
ord-92cc063dd96c444ea99dcc95c4f90eb9
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

Loading…