反应详情

1-phenyl-1-[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]ethanol (0.675 g, 1.72 mmol) in EtOH (13 mL) is refluxed with conc HCl (2.6 mL) for 2 h. The cooled reaction is poured into water and extracted with methylene chloride. The extract is washed with saturated aq sodium bicarbonate, dried (MgSO4) and concentrated. The residue is chromatographed eluting with 5:95 ethyl acetate:hexane to afford the title compound as a yellow solid (0.546 g, 85%). MS (ESI) m/z 376; HRMS: calcd for C24H16F3N+H, 376.13131; found (ESI, [M+H]+), 376.1306.

1. customThe cooled reaction
2. extractionextracted with methylene chloride
3. washThe extract is washed with saturated aq sodium bicarbonate
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customThe residue is chromatographed
7. washeluting with 5:95 ethyl acetate