(2-Fluorophenyl)acetaldehyde → 3-[3-(2-Fluorophenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

HRID 2104615Notes

Reaction equation

HRID 2104615 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)=O.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][CH:29]=O>>[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[C:28]1[CH:29]=[N:1][C:2]2[C:3]([C:12]=1[C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1)=[CH:4][CH:5]=[CH:6][C:7]=2[C:8]([F:11])([F:10])[F:9]

Participants

3

Reactant 2

HCID 17770161(2-Fluorophenyl)acetaldehydeHCID 66586253[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone

Product 1

HCID 669139013-[3-(2-Fluorophenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

Procedure

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and (2-Fluoro-phenyl)-acetaldehyde following the procedure of Example 457: mp 186-187° C.; MS m/z 384, HRMS: calcd for C22H13F4NO+H+, 384.10060; found (ESI, [M+H]+), 384.1.

Sources & evidence

ORD record
ord-3fd0839483eb4bef83f61c2a67bf50b4
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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