HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Fluorophenyl)acetaldehyde → 3-[3-(2-Fluorophenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Fluorophenyl)acetaldehyde | HCID 17770161 | — |
| Reactant | [2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone | HCID 66586253 | — |
| Product | 3-[3-(2-Fluorophenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol | HCID 66913901 | — |
Reaction Steps
The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and (2-Fluoro-phenyl)-acetaldehyde following the procedure of Example 457: mp 186-187° C.; MS m/z 384, HRMS: calcd for C22H13F4NO+H+, 384.10060; found (ESI, [M+H]+), 384.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576215B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-3fd0839483eb4bef83f61c2a67bf50b4 |
| Source note | uspto-grants-2009_08 |