4-Methoxyphenylacetaldehyde → 3-[3-(4-Methoxyphenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

HRID 2104620Notes

Reaction equation

HRID 2104620 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)=O.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH:30]=O)=[CH:25][CH:24]=1>>[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:30]=[N:1][C:2]3[C:3]([C:12]=2[C:14]2[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=2)=[CH:4][CH:5]=[CH:6][C:7]=3[C:8]([F:11])([F:10])[F:9])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 797824-MethoxyphenylacetaldehydeHCID 66586253[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone

Product 1

HCID 669137513-[3-(4-Methoxyphenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

Procedure

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and (4-Methoxy-phenyl)-acetaldehyde following the procedure of Example 457: MS (ESI) m/z 396; HRMS: calcd for C23H16F3NO2+H+, 396.12059; found (ESI, [M+H]+), 396.1195.

Sources & evidence

ORD record
ord-46add86abfd14580a2c03d53e38cec65
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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