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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104620Generated: October 31, 2026

4-Methoxyphenylacetaldehyde → 3-[3-(4-Methoxyphenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

https://huagongshe.com/reaction/2104620

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethoxyphenylacetaldehydeHCID 79782—
Reactant[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanoneHCID 66586253—
Product3-[3-(4-Methoxyphenyl)-8-(trifluoromethyl)quinolin-4-yl]phenolHCID 66913751—

Reaction Steps

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and (4-Methoxy-phenyl)-acetaldehyde following the procedure of Example 457: MS (ESI) m/z 396; HRMS: calcd for C23H16F3NO2+H+, 396.12059; found (ESI, [M+H]+), 396.1195.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576215B2
Source datasetuspto-grants-2009_08
ORD IDord-46add86abfd14580a2c03d53e38cec65
Source noteuspto-grants-2009_08