Benzeneacetaldehyde, 3-methyl- → 3-[3-(3-Methylphenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

HRID 2104621Notes

Reaction equation

HRID 2104621 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)=O.[C:21]1([CH3:30])[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][CH:28]=O)[CH:22]=1>>[CH3:30][C:21]1[CH:22]=[C:23]([C:27]2[CH:28]=[N:1][C:2]3[C:3]([C:12]=2[C:14]2[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=2)=[CH:4][CH:5]=[CH:6][C:7]=3[C:8]([F:11])([F:10])[F:9])[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 175272Benzeneacetaldehyde, 3-methyl-HCID 66586253[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone

Product 1

HCID 669141583-[3-(3-Methylphenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

Procedure

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and m-Tolyl-acetaldehyde following the procedure of Example 457: MS (ES) m/z 378.0; HRMS: calcd for C23H16F3NO+H+, 380.12567; found (ESI, [M+H]+), 380.1263.

Sources & evidence

ORD record
ord-18a7aa0c7d7f440eafc450720771fc46
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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