2-(2,4,6-Trimethylphenyl)acetaldehyde → 3-[3-Mesityl-8-(Trifluoromethyl)Quinolin-4-yl]Phenol

HRID 2104622Notes

Reaction equation

HRID 2104622 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)=O.[CH3:21][C:22]1[CH:27]=[C:26]([CH3:28])[CH:25]=[C:24]([CH3:29])[C:23]=1[CH2:30][CH:31]=O>>[C:22]1([CH3:21])[CH:27]=[C:26]([CH3:28])[CH:25]=[C:24]([CH3:29])[C:23]=1[C:30]1[CH:31]=[N:1][C:2]2[C:3]([C:12]=1[C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1)=[CH:4][CH:5]=[CH:6][C:7]=2[C:8]([F:11])([F:10])[F:9]

Participants

3

Reactant 2

HCID 3003822-(2,4,6-Trimethylphenyl)acetaldehydeHCID 66586253[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone

Product 1

HCID 669144823-[3-Mesityl-8-(Trifluoromethyl)Quinolin-4-yl]Phenol

Procedure

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and (2,4,6-Trimethyl-phenyl)-acetaldehyde following the procedure of Example 457: MS (ES) m/z 405.9; HRMS: calcd for C25H20F3NO+H+, 408.15697; found (ESI, [M+H]+), 408.1573.

Sources & evidence

ORD record
ord-5df03219e1d047838923be5715e5b9fc
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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