2-(3-(Trifluoromethyl)phenyl)acetaldehyde → 3-{8-(Trifluoromethyl)-3-[3-(Trifluoromethyl)Phenyl]Quinolin-4-yl}Phenol

HRID 2104627Notes

Reaction equation

HRID 2104627 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)=O.[F:21][C:22]([F:33])([F:32])[C:23]1[CH:24]=[C:25]([CH2:29][CH:30]=O)[CH:26]=[CH:27][CH:28]=1>>[F:9][C:8]([F:11])([F:10])[C:7]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:2]=1[N:1]=[CH:30][C:29]([C:25]1[CH:26]=[CH:27][CH:28]=[C:23]([C:22]([F:21])([F:32])[F:33])[CH:24]=1)=[C:12]2[C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 212463392-(3-(Trifluoromethyl)phenyl)acetaldehydeHCID 66586253[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone

Product 1

HCID 865987573-{8-(Trifluoromethyl)-3-[3-(Trifluoromethyl)Phenyl]Quinolin-4-yl}Phenol

Procedure

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and (3-Trifluoromethyl-phenyl)-acetaldehyde following the procedure of Example 457: HRMS: calcd for C23H13F6NO+H+, 434.09741; found (ESI, [M+H]+), 434.0993.

Sources & evidence

ORD record
ord-12fcf43834994e81a94a35afb9d19206
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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