2-Fluoro-3-(trifluoromethyl)benzophenone → [2-Methyl-4-Phenyl-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)Methanone

HRID 2104634Notes

Reaction equation

HRID 2104634 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O.F[C:21]1[C:26](C(F)(F)F)=[CH:25][CH:24]=[CH:23][C:22]=1[C:31]([C:33]1C=CC=[CH:35][CH:34]=1)=[O:32]>>[CH3:35][C:34]1[C:33]([C:31]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:21]=2)=[O:32])=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:3]2[C:2](=[C:7]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:5][CH:4]=2)[N:1]=1

Participants

3

Reactant 2

HCID 27375522-Fluoro-3-(trifluoromethyl)benzophenoneHCID 21555860HCID 21555860, compound

Product 1

HCID 66914452[2-Methyl-4-Phenyl-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)Methanone

Procedure

[2-amino-3-(trifluoromethyl)phenyl](phenyl)methanone: The title compound was prepared from (2-Fluoro-3-trifluoromethyl-phenyl)-phenyl-methanone following the procedure of Example 457, Step 3: MS (ESI) m/z 266; HRMS: calcd for C14H10F3NO+H+, 266.07872; found (ESI, [M+H]+), 266.0771

Sources & evidence

ORD record
ord-fb090ee712ef4382a1c34b2794ea356c
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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