4-(Bromomethyl)benzoic acid → 4-({3-[3-Phenyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Methyl)Benzoic Acid

HRID 2104668Notes

Reaction equation

HRID 2104668 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([C:16]=2[C:17]2[CH:18]=[C:19]([OH:23])[CH:20]=[CH:21][CH:22]=2)=[CH:14][CH:13]=[CH:12][C:11]=3[C:24]([F:27])([F:26])[F:25])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:29][C:30]1[CH:38]=[CH:37][C:33]([C:34]([OH:36])=[O:35])=[CH:32][CH:31]=1>>[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([C:16]=2[C:17]2[CH:18]=[C:19]([CH:20]=[CH:21][CH:22]=2)[O:23][CH2:29][C:30]2[CH:38]=[CH:37][C:33]([C:34]([OH:36])=[O:35])=[CH:32][CH:31]=2)=[CH:14][CH:13]=[CH:12][C:11]=3[C:24]([F:27])([F:25])[F:26])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 225994-(Bromomethyl)benzoic acidHCID 665862923-(3-Phenyl-8-trifluoromethyl-quinolin-4-yl)-phenol

Product 1

HCID 669141724-({3-[3-Phenyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Methyl)Benzoic Acid

Procedure

The title compound was prepared from [3-(3-Phenyl-8-trifluoromethyl-quinolin-4-yl)-phenol and 4-Bromomethyl-benzoic acid following the procedure of Example 1: mp 108-112° C.; MS m/z 500; HRMS: calcd for C30H20F3NO3+H+, 500.14680; found (ESI, [M+H]+), 500.1461.

Sources & evidence

ORD record
ord-c154594799bb4e8bb91fed83d22089f8
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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