4-(Bromomethyl)-3-fluorobenzoic acid → 4-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl] Phenoxy}Methyl)-3-Fluorobenzoic Acid

HRID 2104670Notes

Reaction equation

HRID 2104670 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:30][C:31]1[CH:39]=[CH:38][C:34]([C:35]([OH:37])=[O:36])=[CH:33][C:32]=1[F:40]>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[O:24][CH2:30][C:31]1[CH:39]=[CH:38][C:34]([C:35]([OH:37])=[O:36])=[CH:33][C:32]=1[F:40])=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 151299294-(Bromomethyl)-3-fluorobenzoic acidHCID 536307553-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol

Product 1

HCID 669135574-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl] Phenoxy}Methyl)-3-Fluorobenzoic Acid

Procedure

The title compound was prepared from 3-(3-Benzyl-8-trifluoromethyl-quinolin-4-yl)-phenol and 4-Bromomethyl-3-fluoro-benzoic acid following the procedure of Example 478: MS m/z 532; MS m/z 530; HRMS: calcd for C31H21F4NO3+H+, 532.15303; found (ESI, [M+H]+), 532.153;

Sources & evidence

ORD record
ord-ef069c005d174e28bd79087ec40cfbd0
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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